Protein Details: Cation channel sperm-associated auxiliary subunit zeta

Protein ID

ICDB_Pro_1466

Protein Name

Cation channel sperm-associated auxiliary subunit zeta

Gene Name

Catsperz; Tex40

Organism

Mus musculus (Mouse)

Length

194 amino acids

AlphaFoldDB

AF-Q9CQP8-F1-model_v4.pdb

Function

Auxiliary component of the CatSper complex; a complex involved in sperm cell hyperactivation. Sperm cell hyperactivation is needed for sperm motility which is essential late in the preparation of sperm for fertilization. Required for a distribution of the CatSper complex in linear quadrilateral nanodomains along the flagellum; maximizing fertilization inside the mammalian female reproductive tract. Together with EFCAB9; associates with the CatSper channel pore and is required for the two-row structure of each single CatSper channel.

Sequence

MEESVKPVPKHANHRRSSVRSSLYGDVRDLWSTATMSTANVSVSDVCEDFDEEGKSVRNRIRKYSQTISIRDSLNLEPEEIQQQARRELELCHGRSLEHGEDHEESETSLASSTSESLIFSLWKPHRTYWTEQQNRLPLPLMELMETEVLDILKKALITYRSTIGRNHFMTKELQGYIEGIRKRRNKRLYFLDQ

PDB Structures

7EEB

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

Testis-specific. Expressed in adult but not in fetal testis. Not expressed in ovary. Not expressed in ovary. Not expressed in ovary. Within testis; expression is restricted to spermatids

DOI ID

10.1126/science.1112014; 10.1101/gr.2596504; 10.1038/jhg.2010.26

RefSeq

NP_001034583.1